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Frequently Asked Questions

NABP NAPLEX Sample Question Answers

Question # 1

If you mix 30 gm 5% lidocaine cream and 90gm of 0.5% hydrocortisone cream, whatpercent of lidocaine and hydrocortisone do you have as the end product?

A. Lidocaine/Hydrocortisone 2%/1.25%
B. Lidocaine/Hydrocortisone 0.375%/0.15%
C. Lidocaine/Hydrocortisone 1.25 %/ 0.15%
D. Lidocaine/Hydrocortisone 2% /0.25%
E. Lidocaine/Hydrocortisone 1.25% /0.375%

Question # 2

JK is a 67 years old African American man who presents to your clinic for his bloodpressure management. His past medical history includes Peptic ulcer disease andhypertension. His two BP readings are 160/98, 159/96 and HR 85. He says he has beenadherent to his medication and lifestyle. He currently takes 12.5mg Chlorthalidone andPrilosec 20mg daily.Which of the following is the best strategy to manage his blood pressure?

A. Increase chlorthalidone to 25mg daily
B. Add Norvasc 2.5 daily
C. Add Lisinopril 5mg daily
D. Add hydrochlorothiazide 25mg daily
E. Add Lisinopril 20mg daily

Question # 3

What is the active ingredient of the medicine Lyrica?

A. Tramadol
B. Digoxin.
C. Valproate
D. Pregabalin

Question # 4

A patient presents in the pharmacy in a delirious state with pinpoint pupils. Which of thefollowing toxicity states does the patient most likely have?

A. Alcohol
B. Opioid
C. Benzodiazepine
D. Amphetamine

Question # 5

What vitamin should the a patient receive to avoid Wernicke- Korsakoff syndrome?

A. Thiamine
B. Cyanocobalamin
C. Folic Acid
D. Nicotinic Acid
E. Magnesium

Question # 6

Which of these medicines is well-known to cause a positive direct Coombs test?

A. Methyldopa
B. Labetalol
C. Hydralazine
D. Nifedipine

Question # 7

Which of the following side effects should LT be made aware of while on DivalproexSodium?

A. Weight gain
B. Oligomenorrhea
C. Alopecia
D. Gynecomastia
E. Gingival hyperplasia

Question # 8

A Physician orders Dobutamine HCl IV infusion at 5 mcg/kg/min. Dobutamine HCl isavailable as 500 mg in 250 mL of D5W. The patient weighs 68 kg. Calculate the infusionrate in mL/hr.

A. 10.2mls/hr
B. 5.2mls/hr
C. 0.17mls/hr
D. 22.4mls/hr
E. 340mls/hr

Question # 9

An 11-year-old male presents with his mother to your clinic with 5 days of frequentdiarrhea, occasionally with streaks of blood mixed in. Stool cultures are pending, butpreliminary stool samples demonstrate fecal WBC and RBC.Assuming the patient is stable enough for outpatient management, what would be theoptimal treatment assuming the underlying pathogen is Shigella?

A. Oral Erythromycin
B. Oral Metronidazole
C. Oral Vancomycin
D. An oral quinolone
E. Oral TMP-SMX

Question # 10

Which of the following medication may increase LDL?

A. Lisinopril
B. Hydrochlorothiazide
C. Diltiazem
D. Metoprolol
E. Amlodipine

Question # 11

Which of the following would be most appropriate to treat stenotrophomonas maltophilia?

A. Meropenem
B. Vancomycin
C. Ciprofloxacin
D. Sulfamethoxazole/trimethoprim
E. Cefepime

Question # 12

What is the amount of potassium permanganate in 300mL of a 1 in 25 solution?

A. 1 gram
B. 8 grams
C. 12 grams
D. 14 grams

Question # 13

CJ is a 69-year-old male with a history of diabetes, hypertension and hypercholesterolemia.His fasting lipid profile is TC 530 mg/dL; LDL-C 125; HDL-C 48 mg/dL; and TG 640 mg/dL.His A1c 8.1, calculate creatinine clearance is 65mls/hr, BP 135/80 mm Hg, HR 70 beats/min.His current medications include metformin 1000mg po bid, lisinopril 20mg daily, sitagliptin50mg bid and atorvastatin 40mg daily.What is the best pharmacological agent to initiate on CJ?

A. Increase atorvastatin to 80mg
B. Niacin 500mg twice daily
C. Fenofibrate 162mg daily
D. Gemfibrozil 600mg twice daily
E. Fish oil 500mg twice daily

Question # 14

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches,weight 85 kg and NKDA.His past medical history includes hypertension, diabetes mellitus, major depression,hypothyroidism and chronic back pain. Post-op day 1, LN’s medication includesDexamethasone 8mg iv q6h with taper dosing, Ondansetron 4 mg iv q6h prn for N/V,Levothyroxine 0.075 mg po daily, Lisinopril 10 mg po daily, Citalopram 20 mg po daily,Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10mg suppository daily prn forconstipation, Famotidine 20 mg iv q12hr, Metoclopramide 10 mg iv q6h, Metformin 500 mgpo bid, D51/2NS with 20K at 125 mls/hour and Hydromorphone PCA at 0.2 mg/hour ofbasal rate, demand dose 0.1 mg. lock- out every 6min, one hour limit 2.2 mg/hour.Pertinent morning labs includes serum creatinine 1.4 mg/dl, Mg 1.5 mg/dl, K 5.0 mmol/L,Na 135 mmol/L.Which of the following medication may increase LN’s potassium?

A. Ondansetron
B. Metoclopramide
C. Metformin
D. Lisinopril
E. Hydromorphone

Question # 15

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches,weight 85 kg and NKDA.His past medical history includes hypertension, diabetes mellitus, major depression,hypothyroidism and chronic back pain. Post-op day 1, LN’s medication includesDexamethasone 8mg iv q6h with taper dosing, Ondansetron 4mg iv q6h prn for N/V,Levothyroxine 0.075mg po daily, Lisinopril 10mg po daily, Citalopram 20mg po daily,Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10mg suppository daily prn forconstipation, Famotidine 20mg iv q12hr, Metoclopramide 10mg iv q6h, Metformin 500mgpo bid, D51/2NS with 20K at 125mls/hour and Hydromorphone PCA at 0.2mg/hour of basalrate, demand dose 0.1mg. lock-outevery 6min, one hour limit 2.2mg/hour. Pertinent morning labs includes serum creatinine1.4mg/dl, Mg 1.5mg/ dl, K 5.0mmol/L, Na 135mmol/L.Which of the following medication’s dose are adjusted for poor renal function?

A. Famotidine
B. Metoclopramide
C. Lisinopril
D. Citalopram
E. Ondansetron

Question # 16

Which of the following class of antidiabetic medications can increase triglycerides?

A. Bile acid sequestrant
B. GLP-1 agonist
C. Thiazolidinediones
D. SGLT2 Inhibitor
E. Alpha-glucosidase inhibitors

Question # 17

You need 51.3 mEq of NaCl to make 1/3 NS 1 liter bag. How many ml of 23.4% NaClwould you need? (Molecular weight of Na is 23 and Cl is 35.5)

A. 12.82ml B. 16.82ml
B. 23.4ml
C. 58.5ml
D. 10ml

Question # 18

Which of the following illnesses is an example of a type III hypersensitivity reaction?

A. Lupus
B. Graves disease
C. Hashiomoto’s thyroiditis
D. Allergic rhinitis
E. Myasthenia gravis

Question # 19

JM is a 32-year-old women who comes to your diabetic clinic with complain of severalepisodes of hypoglycemia. She is on Insulin NPH/regular 70/30, 22 units twice a day with breakfast and dinner. 8 units with lunch.After discussing with physician you decide to decrease the total daily insulin by 10% andchange to insulin glargine once a day and Insulin Lispro three time a day at ratio of 50:50 –50 % of long and 50 % of short acting insulin.What is her new insulin regimen? Round down to the nearest 1 unit.

A. 16 units of insulin glargine once daily, Insulin Lispro 4 units 3 times a day with meals
B. 15 units of insulin glargine once daily, Insulin Lispro 5 units 3 times a day with meals
C. 23 units of insulin glargine once daily, Insulin Lispro 7 units 3 times a day with meals
D. 30 units of insulin glargine once daily, Insulin Lispro 6 units 3 times a day with meals
E. 18 units of insulin glargine once daily, Insulin Lispro 6 units 3 times a day with meals

Question # 20

The rate that an outcome will occur given a particular exposure, compared to the rate of theoutcome occurring in the absence of that exposure is definition of which of the following?

A. Incidence rate
B. Prevelance rate
C. Odds ratio
D. Relative risk
E. Confidence Interval

Question # 21

A 20-year-old student came to the emergency department with primary complaints ofpalpitations, low-grade fever, and anxiety for 2 months. She reports that she is irritable andsuffers severe mood swings that is interfering with her sleep and relationships (she admitsto crying spells and frequent fights with friends and family). She has also lost 12 pounds inthe past 2 months with no apparent alteration in her diet or physical activity (though she ishappy with her weight loss). She denies any past medical problems, though her friendshave always been worried that she eats too little.Her temperature is 38.0 C (100.4 F), blood pressure is 148/62 mm Hg, pulse is 122/minand regular, and respiratory rate is 28/min. Examination reveals a bruit heard over theanterior neck, fine tremor of the hands, and warm, moist skin. Her eyes and eyelids do notmove together during finger following test (with steady head). Laboratory work is sent,including a thyroid panel, but will not be available until tomorrow morning.Which of the following is the most appropriate initial management at this time?

A. Diltiazem therapy
B. Iodine therapy
C. Methimazole therapy
D. Propranolol therapy
E. Referral to a surgeon

Question # 22

A 23-year-old female presents to your clinic complaining of intermittent throbbingheadaches that usually last for several hours and are made worse by the presence of light.She endorses occasional nausea without vomiting during the most severe episodes.Physical examination is unrevealing, and she has no significant past medical history.Which of the following treatments is considered an abortive therapy for this patient’sunderlying condition?

A. Sumatriptan
B. Gabapentin
C. Amitriptyline
D. Propranolol
E. Diltiazam

Question # 23

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches,weight 85 kg and NKDA.His past medical history includes hypertension, diabetes mellitus, major depression,hypothyroidism and chronic back pain. Post-op day 1, LN’s medication includesDexamethasone 8 mg iv q6h with taper dosing, Ondansetron 4 mg iv q6h prn for N/V,Levothyroxine 0.075 mg po daily, Lisinopril 10 mg po daily, Citalopram 20 mg po daily,Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10 mg suppository daily prn forconstipation, Famotidine 20 mg iv q12hr, Metoclopramide 10 mg iv q6h, Metformin 500 mgpo bid, D51/2NS with 20K at 125mls/hour and Hydromorphone PCA at 0.2 mg/hour ofbasal rate, demand dose 0.1 mg. lock-out every 6min, one hour limit 2.2 mg/hour. Pertinentmorning labs includes serum creatinine 1.4 mg/dl, Mg 1.5 mg/dl, K 5.0 mmol/L, Na 135mmol/L.Which of the following medication may significantly cause QT prolongation?

A. Lisinopril
B. Levothyroxine
C. Metformin
D. Hydromorphone
E. Citalopram

Question # 24

Which of the following antidiabetic medication works by inhibiting carbohydratebreakdown?

A. Acarbose
B. Metformin
C. Dapagliflozin
D. Pioglitazone
E. Sitagliptin

Question # 25

A 27-year-old female with ovarian cancer is undergoing chemotherapy. She developssubsequent renal failure.Which of the following drugs is most likely responsible for this?

A. Cyclophosphamide
B. Bleomycin
C. Cisplatin
D. Vinblastine
E. Vincristine

Question # 26

You prescribe doxepin to a 37-year-old woman to treat neurotic excoriations on her arms.The patient is concerned about the side effects of this drug. Which of the following is not aside effect of doxepin:

A. Xerostomia
B. Liver toxicity
C. Somnolence
D. Urinary retention
E. Constipation

Question # 27

Number of new cases per population at risk in a given time period is a definition of which ofthe following?

A. Incidence rate
B. Prevalence rate
C. Mortality rate
D. Odds ratio
E. Confidence Interval

Question # 28

How many kcal per gram does IV dextrose provide?

A. 0.9 kcal/g
B. 1.2 kcal/g
C. 1.5 kcal/g
D. 3.4 kcal/g

Question # 29

What is the best anti-thyroid regimen in a pregnant woman who has clinically significant hyperthyroidism?

A. Stop treatment and resume post-partum
B. Propylthiouracil
C. Methimazole
D. Propylthiouracil first trimester followed by methimazole for the remainder of pregnancy
E. Methimazole first trimester followed by propylthiouracil for the remainder of pregnancy

Question # 30

What is the standard oral weekly dose of alendronate given to treat osteoporosis?

A. 10mg
B. 70mg
C. 140mg
D. 200mg

Question # 31

A fasting blood glucose level greater than what value is an indicator of type 2 diabetes?

A. 5 mmol/L
B. 6 mmol/L
C. 7 mmol/L
D. 8 mmol/L
E. 9 mmol/L

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